Sarah Silverman should just be thrilled she was nominated. I personally think it was well-deserved, but I think she'll have to wait for this one.
Mary-Louise Parker is one of the most talented actresses around, and year after year she gives an incredible performance in Weeds, and every year she submits poorly, why should this year be any different.
Julia Louis-Dreyfus is a legend, and always has a shot, since the Emmys tend to over-reward. However Old Christine isn't getting any funnier, let's face it, it's not Seinfeld.
Christina Applegate bubbles in every scene, but with the cancelling of Samantha Who? it is going to be hard for her to to claim a belated trophy. But she definately has a shot though, so don't count her out.
Ok, so then it comes down to two. Toni Collette does a great job in the very baity United States of Tara. However, overall I find the show kind of annoying, and I think that overall show problems could prevent her from winning, despite her personal triumph.
But the real reason she will not win can be summed up in two words: Tina Fey. Need I say more.