I think Chazelle, Jenkins and Lonergan are locks. Look out for Scorsese, Gibson, Davis, Ford, Eastwood, Melfi, Nichols, and particularly MacKenzie
Denis Villeneuve "Arrival"
Denzel Washington "Fences"
Damien Chazelle "La La Land"
Kenneth Lonergan "Manchester By the Sea"
Barry Jenkins "Moonlight"